気管支喘息における抗原特異的T cell cloneの樹立とサイトカイン産生能に関する研究

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  • Establishment of antigen specific T cell clones from asthmatic patients including evaluation of cytokine production

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To clarify the pathogenesis of bronchial asthma, we established T cell clones specific for Candida antigen and for mite antigen from the peripheral blood of three asthmatic patients. Flow cytometric analysis was performed on these clones. The surface phenotype of all clones was helper/inducer type. These clones were analyzed for the ability to produce interferon gamma (IFN-γ) and interleukin 4 (IL-4).<br>The T cell clone established from the patient who showed late asthmatic response (LAR) after bronchial inhalation of Candida, as well as the clones from the patient who showed IAR and LAR after inhalation of housedust mite, produced a higher amount of IFN-γ and lower amount of IL-4. The T cell clone established from the patient who were under corticosteroid therapy and showed IAR after inhalation of Candida produced lower amounts of IFN-γ and IL-4, which seemed to be inhibition of cytokine production from antigen specific T cell clone by corticosteroids.<br>These findngs indicate that T cell clones established from the patients who showed LAR produced a large amount of IFN-γ, suggesting that IFN-γ plays an important role in allergic reactions of LAR.

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